|
KMID : 0032220110230040529
|
|
Annals of Dermatology
2011 Volume.23 No. 4 p.529 ~ p.535
|
|
|
CD20 Positive T Cell Lymphoma Involvement of Skin
|
|
Lee Ki-Yeol
Jeon Su-Young
Hong Jin-Woo
Kim Young-Hun
Song Ki-Hoon
Kim Ki-Ho
|
|
|
Abstract
|
|
|
|
CD20 positive T cell lymphoma is a rare condition that is associated with the coexpressions of CD20 and T cell markers, such as, CD3, CD5, or UCHL-1. Positivity for CD20 in this tumor represents an aberrant immunophenotype, but the presence of monoclonal T cell receptor (TCR) gene rearrangements and negativity for immunoglobulin heavy chain gene rearrangement indicate that this tumor is a T cell lymphoma. The majority of cases of CD20 positive T cell lymphoma have been reported as immature peripheral T cell lymphoma not otherwise specified. However, we believe that this disease is likely to be re-listed as a new disease entity after its pathogenesis has been elucidated and more cases have been evaluated. Here, we present a case of peripheral T cell lymphoma coexpressing CD20 and T cell markers with a demonstrable TCR gene rearrangement, in a patient who had been misdiagnosed as having B cell type lymphoma 4 years previously. We hypothesize that in this case initially circulating normal CD20+ T cell subsets underwent neoplastic transformation and CD20 positive T cell lymphoma subsequently developed in the lymph node, and then recurred in the skin due to systemic disease or metastasized from the nodal disease.
|
|
|
KEYWORD
|
|
|
CD20, T cell lymphoma, T cell receptor gene arrangement
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
   
|